Iloprost With and Without rt-PA: Treatment of 131 Cases of Severe Frostbite

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A controlled trial of a prostacyclin and rt-PA in the treatment of severe frostbite.

n engl j med 364;2 nejm.org january 13, 2011 189 described in the published reports,1,2 this calculation was erroneously made on the basis of the right eye only, resulting in fewer events as well as fewer people in whom a change in visual acuity could be ascertained. The published and revised numbers are presented in Table 1; the article is correct at NEJM.org. These changes do not materially c...

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131 - Hypothermia and Frostbite

Accidental hypothermia is generally manifested as progression from an initial state of catecholamine release and stimulation (mild hypothermia) to one marked by a predictable slowing of metabolism and all critical body functions to the extent that patients may appear dead. The profound physiologic changes and metabolic slowing all reverse with rapid rewarming, and reports of remarkable neurolog...

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Despite advances in outdoor clothing and medical management of frostbite, individuals still experience catastrophic amputations. This is a particular risk for those in austere environments, due to resource limitations and delayed definitive treatment. The emerging best therapies for severe frostbite are thrombolytics and iloprost. However, they must be started within 24 hours after rewarming fo...

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ژورنال

عنوان ژورنال: Wilderness & Environmental Medicine

سال: 2016

ISSN: 1080-6032

DOI: 10.1016/j.wem.2016.06.029